WELCOME ! Hello. Welcome on XLH Research ! This website is dedicated to the scientific research on X-Linked Hypophosphatemic Rickets (XLHR or XLH). XLH is a monogenic hereditary disease caused by mutation of the phex gene on the X chromosome. For decades, the treatment of XLH relied on oral phosphate supplementation and pharmacologic correction of the hypocalcitriolemia with oral calcitriol. The efficiency of this treatment is however often limited and not devoided of side effects. Therefore, new treatment options are needed ! But to enable those, a better understanding of the disease is key: identifying the molecular nature of the pathologic phosphate wasting signal, dissecting the molecular pathways involved in the integration of this signal, harnessing potential control mechanisms... In the last 10 years, scientists have made significant progress in this direction and today several new approaches are being explored. The most advanced is even in the clinic and may reach the (adult) patients in 5 to 7 years. Let’s follow the adding steps of this quest towards a cure for XLH as they appear ! XLH Research 2012 Réalisé avec Xara